
Summer Science Program
Curing citruses: Aurintricarboxylic acid as a potential novel fungicide targeting Cdc14 in Penicillium digitatum
During the summer of 2023, I attended the Summer Science Program, Biochemistry at Indiana University, Bloomington for 5.5 weeks. Working with three other students from across the United States, I studied the viability of targeting the Cdc14 enzyme in Penicillium digitatum for the production of a novel fungicide. First, I expressed and characterized the Cdc14 enzymes before testing dozens of small molecules to isolate the best inhibitor. From there, I used the Molecular Operating Environment (MOE) to create a novel small molecule inhibitor, ultimately concluding that a modified version of Aurintricarboxylic acid would serve as the prime inhibitor of Cdc14 in P. digitatum.
